Put into bat by Melbourne Renegades, Healy started with a couple of boundaries off Sophie Molineux in the second over and then hit Hayley Matthews for a maximum.
In the 12th over, Bates reached her fifty from 34 balls and Healy joined her in the next over as the duo brought up their century partnership as well. Post her fifty, Healy hit two more sixes to take Sixers to the 150-run mark.
Eventually in the 17th over, Molineux struck twice to remove both the openers but not before they added 151 runs for the opening wicket. Bates was caught by Shabnim Ismail for 66, while the left-armer bowled Healy for 78.
A couple of aggressive cameos from Ashleigh Gardner and Erin Burns took Sixers over 180 and Ellyse Perry finished the innings with a first-ball boundary.
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In reply, Renegades were in dire straits losing five wickets with only 38 runs on the board by the time eighth over finished. Sophie Ecclestone took couple of early wickets including the big won off Matthews and Lauren Cheatle snared Molineux and Chamari Athapaththu.
It was up to Carly Leeson to lead the recovery for Renegades and she found a company in Rhiann O'Donnell. Together they added 81 runs for the sixth wicket although target always seemed out of reach.
The duo did make a dash for the target and they took on Stella Campbell and Perry to plunder 22 and 24 runs respectively off their solitary overs. Both the pacers struggled with their lines and gave away a few extras. Campbell, in particular, started with five wide deliveries whereas Perry bowled a ball for five-wides before bowling a no-ball.
However, once Maitlan Brown dismissed O’Donnell, wind was knocked out of Renegades’ chase. Leeson top-scored with 52 as they finished the innings on 151 for nine from the stipulated 20 overs. For Sixers, Cheatle and Brown picked up three wickets each.
Brief Scores: Sydney Sixers 188/3 in 20 overs (Alyssa Healy 78, Suzie Bates 66; Sophie Molineux 2/38) beat Melbourne Renegades 151/9 in 20 overs (Carly Leeason 52, Rhiann O'Donnell 32; Maitlan Brown 3/16, Lauren Cheatle 3/28) by 37 runs POTM: Alyssa Healy